S.N | miRNAs | Validated Gene targets | Function of miRNAs | Expression of miRNAs | References |
---|---|---|---|---|---|
1 | miR-21 | PTEN, RECK, PDCD4 | Anti-apoptotic activity, promotes metastasis and invasion | [122, 123] | |
2. | miR-106b | E2F1, RhoGTPases, RhoA, RhoC | Promotes cell migration and actin stress fibre formation | [120] | |
3. | miR-17-5p | p38, MAPK pathway, E2F-1, c-MYC | Promotes malignancy and metastasis | [2, 124] | |
4. | miR- 151 | RhoGDIA, FAK, | Promotes tumour metastasis and invasion | [125, 126] | |
5. | miR-122 | CyclinG1, ADAM10, SRF, IGF1R, PTTG1, PBF, CUTL1,NDRG3,MDR-1 |
Responsible for inhibition of virus replication and cell proliferation | [127, 128] | |
6. | miR-143 | FNDC3B | Promotes tumour metastasis | [129] | |
7. | miR-210 | VMP1 | Promotes hypoxia induced epithelial to mesenchymal transition | [130] | |
8. | miR-29 | MEG3, Bcl-2, Mcl-1 | Promotion of apoptosis and inhibition of tumour growth |
[119] | |
9. | let-7 | cMyc, p16, Bcl-xl, COLIA2 | Inhibit cell growth and proliferation | [131] | |
10. | miR-26a | Cyclin D2, Cyclin E2, Cyclin E1,CDK6, IL-6 |
Inhibit metastasis, invasion and tumour growth | [132] | |
11. | miR-221 | CDKN1B/p27,CDKN1C/p57, DDIT4,PTEN, Bmf, TIMP3, PPP2R2A | Anti-apoptotic, help in metastasis and tumour growth. | [118, 133] | |
12. | miR-1 | FoxP1, MET, HDAC4 | Inhibition of cell growth and reduced replication potential |
[134] | |
13. | miR-195 | cyclin D1, CDK6, E2F3, LATS2,VEGF, VAV2, CDC42, IKKα and TAB3, TNF-α/NF-κB pathway | Inhibit metastasis, G1/S transition, angiogenesis and helps in apoptosis. | [135] | |
14. | miR-45 | OCT4, IRS1, IRS2, IGF signaling,HDAC2 | Inhibit cell proliferation, migration, and invasion |
[136, 137] | |
15. | miR-224 | API-5, CDC42, CDH1, PAK2, BCL-2,MAPK1, PPP2R1B. . |
Promote cell proliferation,migration, invasion, andinhibit cell apoptosis | [138, 139] |