Table 2: Venous blood analyte values from collected Titmice based on age, sex, and midazolam administration.
Means, standard error, and sample size of untransformed values reported for reference purposes. Probability values from means' significance testing provided with two degrees of freedom. Significant values (α ≤ 0.05) are shown in bold. |
a. Age |
Analyte |
Units |
n |
Juvenile |
n |
Adult |
p |
pHNT
|
at 37°C |
21 |
7.56 ±0.01 |
29 |
7.59 ±0.01 |
0.09 |
pO2
|
mmHg |
21 |
34.5 ±1.1 |
30 |
35.2 ±0.8 |
0.61 |
sO2
|
% |
21 |
75 ±2 |
29 |
78 ±1 |
0.13 |
pCO2
|
mmHg |
21 |
28.7 ±1.2 |
29 |
28.2 ±1.1 |
0.75 |
HCO3
|
mmol L-1
|
21 |
25.0 ±0.9 |
29 |
27.0 ±0.8 |
0.09 |
tCO2NT
|
mmol L-1
|
21 |
26.1 ±0.8 |
29 |
27.8 ±0.8 |
0.16 |
BEecf |
mmol L-1
|
21 |
3.2 ±0.9 |
29 |
5.3 ±0.9 |
0.10 |
LactateNT
|
mmol L-1
|
16 |
3.8 ±0.3 |
26 |
3.8 ±0.2 |
0.98 |
Glucose |
mg dL-1
|
20 |
339.4 ±13.5 |
28 |
322.3 ±12.2 |
0.36 |
Na+
|
mmol L-1
|
20 |
158.5 ±1.0 |
28 |
158.7 ±0.7 |
0.80 |
K+
|
mmol L-1
|
20 |
3.7 ±0.1, 20 |
28 |
3.7 ±0.1 |
0.99 |
Cl-
|
mmol L-1
|
15 |
119.6 ±1.1 |
25 |
119.0 ±0.9 |
0.67 |
BUNT
|
mg dL-1
|
15 |
1.8 ±0.2 |
25 |
1.6 ±0.2 |
0.61M
|
PCV |
% |
17 |
58 ±2 |
31 |
58 ±1 |
0.87 |
HctNT
|
% PCV |
20 |
42 ±1 |
28 |
44 ±1 |
0.07W
|
HbNT
|
g dL-1
|
20 |
14.0 ±0.2 |
28 |
15.0 ±0.3 |
0.06W
|
b. Sex |
Analyte |
Units |
n |
Female |
n |
Male |
p |
pHNT
|
at 37°C |
18 |
7.60 ±0.01 |
31 |
7.59 ±0.01 |
0.15 |
pO2
|
mmHg |
18 |
33.6 ±1.0 |
31 |
35.5 ±0.8 |
0.16 |
sO2
|
% |
18 |
74 ±2 |
31 |
78 ±1 |
0.06 |
pCO2
|
mmHg |
18 |
28.6 ±1.1 |
31 |
28.9 ±1.1 |
0.95 |
HCO3
|
mmol L-1
|
18 |
25.5 ±0.8 |
31 |
27.4 ±0.9 |
0.23 |
tCO2NT
|
mmol L-1
|
18 |
25.8 ±1.0 |
31 |
27.7 ±0.8 |
0.13 |
BEecf |
mmol L-1
|
18 |
3.0 ±0.8 |
31 |
5.2 ±0.9 |
0.10 |
LactateNT
|
mmol L-1
|
13 |
3.9 ±0.3 |
28 |
3.8 ±0.2 |
0.77 |
Glucose |
mg dL-1
|
16 |
349.6 ±15.4 |
31 |
317.4 ±11.1 |
0.10 |
Na+
|
mmol L-1
|
16 |
157.8 ±1.1 |
31 |
159.1 ±0.6 |
0.25 |
K+
|
mmol L-1
|
16 |
3.9 ±0.2 |
31 |
3.6 ±0.1 |
0.03 |
Cl-
|
mmol L-1
|
12 |
120.8 ±1.1 |
27 |
118.7 ±0.8 |
0.14 |
BUNT
|
mg dL-1
|
12 |
2.4 ±0.4 |
27 |
1.5 ±0.1 |
0.14M
|
PCV |
% |
15 |
58 ±2 |
32 |
59 ±1 |
0.77 |
HctNT
|
% PCV |
16 |
42 ±1 |
31 |
44 ±1 |
0.04 |
HbNT
|
g dL-1
|
16 |
14.3 ±0.2 |
31 |
14.97 ±0.2 |
0.06 |
c. Midazolam |
Analyte |
Units |
n |
Not Administered |
n |
Administered |
p |
pHNT
|
at 37°C |
28 |
7.59 ±0.02 |
22 |
7.56 ±0.01 |
0.14W
|
pO2
|
mmHg |
28 |
36.4 ±0.8 |
23 |
33.2 ±0.9 |
0.01 |
sO2
|
% |
28 |
80 ±1 |
22 |
72.9 ±1.7 |
0.00 |
pCO2
|
mmHg |
30 |
25.8 ±1.1 |
22 |
31.9 ±0.7 |
<0.001W |
HCO3
|
mmol L-1
|
28 |
24.3 ±0.7 |
22 |
28.5 ±0.8 |
<0.001 |
tCO2NT
|
mmol L-1
|
28 |
25.3 ±0.7 |
22 |
29.4 ±0.8 |
<0.001 |
BEecf |
mmol L-1
|
28 |
3.0 ±0.8 |
22 |
6.3 ±1.0 |
0.01 |
LactateNT
|
mmol L-1
|
19 |
4.8 ±0.2 |
23 |
3.0 ±0.1 |
<0.001 |
Glucose |
mg dL-1
|
25 |
310.0 ±11.6 |
23 |
350.4 ±12.8 |
0.02 |
Na+
|
mmol L-1
|
25 |
157.5 ±0.7 |
23 |
159.8 ±0.7 |
0.02 |
K+
|
mmol L-1
|
25 |
3.8 ±0.1 |
23 |
3.5 ±0.1 |
0.02 |
Cl-
|
mmol L-1
|
17 |
121.3 ±1.0 |
23 |
117.7 ±0.8 |
0.01 |
BUNT
|
mg dL-1
|
17 |
2.3 ±0.2 |
23 |
1.3 ±0.2 |
<0.001M |
PCV |
% |
30 |
58 ±1 |
18 |
58 ±1 |
0.92 |
HctNT
|
% PCV |
25 |
43 ±1 |
23 |
44.0 ±0.9 |
0.49 |
HbNT
|
g dL-1
|
25 |
14.6 ±0.2 |
23 |
14.8 ±0.3 |
0.61 |
NVariable not normally distributed, tested with Shapiro-Wilk Goodness of Fit test for normality.
TVariable transformed to normalize data. 1/exp(x): pH, Log(x): tCO2, Lactate, 1/sqrt(x): BUN, 1/x: Hct, Hb
W Means have unequal variance, p-value provided from Welch's 2 sided F-test
MVariable unable to reach normal distribution, Mann-Whitney ranked score test performed (Mean scores and Z probability provided)
Abbreviations: pO2: partial pressure oxygen, sO2: saturated oxygen, pCO2: partial pressure carbon dioxide, HCO3: bicarbonate, tCO2: total carbon dioxide, BEecf: base excess, Na+: sodium, K+: potassium, Cl-: chloride, BUN: blood urea nitrogen, Hct: hematocrit, Hb: hemoglobin